(in mice) - I get it if it’s some new experimental drug, a mouse probably makes sense to test first. With exercise you’d think they could go straight to humans? Seems like it would be more effort getting mice to lift weights than it’s worth.
Controlled experiments in humans are expensive, time consuming, and actually very difficult to do. Meanwhile any grad student can do a mouse model. The motivation of most academic labs is citations and grants, not useful information. Putting it together…
Selection effects are ridiculously strong for almost anything related to health.
I strongly believe that's why nutrition science is soooo far behind the rest of medicine. There aren't nearly enough serious RCTs (whereas regulations make them abundant for other medical interventions).
We still are in the experimental phase about how we can get two groups of human study participants to keep behaving mostly the same, while also complying with the change in exercise we want data on.
